This event further facilitates the dissociation of the Suppressor of Fused (SuFu) from GLI, allowing GLI activators to regulate target genes.403 Yan et al. demonstrated that the interaction between glioma cells and endothelial cells activates the hedgehog pathway, promoting the transformation of glioma cells into a GSC phenotype.404 The regulation of the hedgehog pathway in CSCs is intricately linked to their emergence and various malignant biological behaviors.405. Here, GLI1 is linked to central nervous system cancer.