PLEK2 and neoplasm: Tumor suppressors miR-873 and miR-30a bind and inhibit patterns of Pleckstrin-2 (PLEK2) and NT5E respectively, leading to downregulation of the PLEK2 or NT5E-mediated PI3K/AKT pathway, thus hindering stemness and tumorigenicity of pancreatic CSCs and GSCs.498,499 Similarly, miR-3187-3p, which can be sponged by circ_0000745, inhibits Erb-B2 Receptor Tyrosine Kinase 4 (ERBB4), thereby attenuating the activity of the PI3K/AKT pathway, exerting a suppressive effect on the tumorigenicity and stemness of ovarian cancer.500