There, they bind to target genes, promoting the transcription of these genes.437 NF-κB activation plays a critical role in the formation of breast CSCs.438 Pathway analysis of CSCs isolated from prostate cancer and NSCLC patient revealed the specific activation of the NF-κB pathway, suggesting its potential as an effective therapeutic target.439,440 Evaluation of the NF-κB signature in patient-derived GSCs can accurately predict the prognosis of low-grade glioma.441. The gene discussed is NFKB1; the disease is Familial prostate cancer.