ALDH1A1 and lung cancer: Ginsenoside Rg3 has been identified as a sensitizing factor for osimertinib by activating the Hippo pathway (Fig. 8b).883 Furthermore, NSCLC cells resistant to erlotinib and afatinib demonstrate enhanced CSCs-related characteristics.884,885 The CSCs’ marker ALDH1A1 has been identified as a critical gene for erlotinib resistance in lung cancer cells.