Tumors can be sustained by proliferative LGR5− cells and, upon cessation of the knockout, LGR5+ CSCs reemerge, leading to rapid tumor regeneration.1030 This suggests that tumor cells with a higher degree of differentiation, following CSC depletion, possess plasticity to revert to the CSC state to compensate for CSC loss. Here, LGR5 is linked to neoplasm.