Deferasirox application effectively downregulates stemness in esophageal cancer and oral cancers.940 High-fat diets activate lipid metabolism via PPARα and PPARδ, enhancing intestinal stem cell function and tumorigenesis.941 Activation of the FOXM1/PRDX3 axis in mitochondria is essential for endometrial CSCs’ survival, suggesting mitochondria as a feasible CSC target.942 Similarly, the mitochondria function-associated FOXM1/PRDX3 pathway is indispensable for colorectal CSCs survival, with its induced upregulation of CD133 expression significantly contributing to colorectal stemness.943. The gene discussed is PRDX3; the disease is lip and oral cavity carcinoma.