CD24, also known as Heat Stable Antigen (HSA), is encoded by the CD24 gene in humans, which also functions as a cell-cell adhesion molecule.360 CD24 also mediates several signaling pathways that could lead to stemness enhancement of tumor cells.361 Likewise, CD44, also known as Homing Cell Adhesion Molecule (HCAM) and Phagocytic Glycoprotein-1 (Pgp-1)also induces cell-cell adhesion and interactions.362 It also takes part in activations of PI3K/AKT and Src/MAPK pathways and serves as a c-Met co-receptor.362 Both molecules can individually or combinedly mark CSCs in several solid tumor types. This evidence concerns the gene AKT1 and neoplasm.