Besides, NO is frequently upregulated in cancers.292 NO disturbs the ubiquitin-mediated prosomal degradation of OCT4 and induces dedifferentiation of human lung cancer cells.151 NO also promotes stem-like properties of mouse glioma cells by activating the Notch pathway.293 Ionizing radiation is one of the inducers of CSCs’ formation across several cancer types,294 which will be discussed in more detail in the CSCs and sensitivity/resistance to radiotherapy section. The gene discussed is POU5F1; the disease is cancer.