Then, the combination of SET And MYND Domain Containing 4 (SMYD4) and unmethylated Nanog promoter will activate the expression of Nanog in those Nanog-negative tumor cells, thus promoting the switch of CSCs.567 Endothelial cells, by expressing miR-126, can induce dormancy in CML stem cells. The gene discussed is NANOG; the disease is neoplasm.