FGF2 and melanoma: Similar results can be obtained by culturing iPSCs with Lewis cell-derived extracellular vesicles162 or recombinant human Fibroblast Growth Factor 2 (FGF2).163 Moreover, mouse embryonic stem cells can also get converted into CSCs in conditioned medium from mouse Lewis lung cancer or melanoma cells.164 These studies provide evidence that CSCs can be induced from normal stem cells, although iPSCs are not equivalent to normal somatic stem cells.