Their combination relieves the inhibition of Tet Methylcytosine Dioxygenase 2 (TET2) and PTEN by inactivating the lncRNA MIR22HG/miR‐22 axis, ultimately attenuating the stemness characteristics of liver cancer and inducing apoptosis of liver CSCs.913 Similarly, ATRA effectively inhibits the expression of cell surface marker CD44 and stemness-related genes ALDH, SOX2, and KLF4 to target gastric CSCs and hinder gastric cancer progression.914. This evidence concerns the gene TET2 and liver cancer.