CD133, also known as Prominin-1 (PROM1) and encoded by the PROM1 gene, belongs to the pentaspan transmembrane glycoproteins family.363 CD133 can activate the PI3K/AKT, Src, and β-Catenin signaling intracellularly to participate in cancer progression.363 CD133 is expressed in a wide range of human tissues and can serve as a CSC marker for various types of solid tumors and hematopoietic malignancies (Tables 2 and 3). This evidence concerns the gene AKT1 and cancer.