LGR5, also known as G-Protein Coupled Receptor 49 (GPR49) or G-Protein Coupled Receptor 67 (GPR67), is encoded by the LGR5 gene.356 LGR5 has been identified as a part of the WNT signaling complex to potentiate the WNT/β-Catenin signaling.357 Given the crucial role of the WNT signaling in cancer stemness, LGR5 has also been identified as a cell-surface marker for several solid tumor types (Table 2). This evidence concerns the gene LGR5 and cancer.