TGFβ-induced enhancement of Snail1 and Zeb1 expression suppresses the miR-499a/SHKBP1 axis, enhancing stemness characteristics and erlotinib resistance (Fig. 8j).905 Conversely, highly expressed Lysyl Oxidase-Like 2 (LOXL2) in oral squamous cell carcinoma correlates positively with the activation of the EMT program and the maintenance of stemness. The gene discussed is TGFB1; the disease is oral cavity squamous cell carcinoma.