STAT3 and central nervous system cancer: IL-17E/IL-25 secreted by non-CSCs binds to IL-17 Receptor B (IL-17RB) on CSCs, activating the JAK/STAT3 pathways to regulate liver CSCs’ stemness.464 Additionally, IL-6 is secreted by regulatory T cells, which upregulates the STAT3 pathway in glioma cells, maintaining the stemness-associated phenotype.465