C-X-C Chemokine Receptor Type 4 (CXCR4), also known as CD184, is a CXC chemokine receptor encoded by the CXCR4 gene.352 The ligand for this receptor is CXCL12.353 CXCR4 is famous for its role as one of the receptors inducing the human immunodeficiency viruses (HIV) infection of T cells.354 CXCR4 is also involved in cancer progression for its role in activating the PI3K/AKT, PLC, hedgehog, ERK1/2, and JAK/STAT pathways.355. The gene discussed is CXCR4; the disease is cancer.