Accumulated TBX3 maintains stemness and promotes metastasis.505 Similarly, CAFs-secreted periostin induces the phosphorylation of FAK to activate AKT, enriching CSCs in the gastric cancer cell population.216 Moreover, Liang et al. demonstrated that inhibition of the PI3K/AKT pathway attenuates the stemness characteristics and angiogenesis of endometrial cancer, which are closely associated with distant metastasis.506,507. The gene discussed is AKT1; the disease is endometrial cancer.