LGALS3 and renal cell adenocarcinoma: C-X-C Motif Chemokine Receptor 2 (CXCR2), upregulated by Galectins-3 (Gal-3), has been identified as a renal cell cancer stemness maintenance factor.930 IL-8 transactivates the EGFR/HER2 pathway through CXCR1 and CXCR2 activation in SRC-dependent manner, ultimately enhancing the stemness characteristics of breast CSCs.931 This further suggests that chemokines can serve as potential targets for controlling CSCs.