In liver CSCs, activation of the PPARα pathway and the enrichment of its downstream factor, Stearoyl-CoA Desaturase 1 (SCD1), contribute to the stemness characteristics.509 Similarly, increased PPARγ activity has been observed in melanoma stem cells.510 Co-culturing MSCs with gastric cancer cells leads to the enrichment of lncRNA Histocompatibility Leukocyte Antigen Complex P5 (HCP5) in MSC-stimulated gastric cancer cells, which sponges miR-3619-5p to promote the expression of PPARG Coactivator 1 Alpha (PPARGC1A). The gene discussed is PPARGC1A; the disease is melanoma.