SLC9C1 and epilepsy: Although extracellular acidosis has been reported to potentiate GABAergic transmission and depress glutamatergic transmission, with a possible role in seizure termination36,38,42,46–48 NHE KO mice display increased excitability and epilepsy indicating that intracellular acidification, followed by H+ extrusion by NHE increases excitability likely through stimulation of ASICs40.