The prognostic significance of 9 potential genes in TCGA-LAML were analyzed by univariate COX regression, and six genes (LGALS1, ALDH1A1, AADAT, ELOVL7, ACOX2, and ACSM3) were significantly correlated with the prognosis of AML patients. The gene discussed is ACOX2; the disease is acute myeloid leukemia.