Therefore, we explored the function in AML using HEL and THP1 cells, and found that suppression of LGALS1 (Fig. S5C, S6A) in THP1 and HEL cells also impaired cell proliferation (Fig. S5D, S6B), enhanced cell apoptosis (Fig. S5E, S6C), and led to a decrease in the fraction of cells in S phase (Fig. 5F, S6D). The gene discussed is LGALS1; the disease is acute myeloid leukemia.