Ferroptosis occurrence is influenced by the exogenous pathway (iron metabolism, amino acid-GSH/GPx4) and the endogenous pathway (endoplasmic reticulum stress, Nrf2/HO-1 signaling pathway, AKT/IKK/P65, and ERK/IKK/P65 signaling pathway cascades), thereby regulating IBD. Here, GPX4 is linked to inflammatory bowel disease.