Gpx4fl/wt LysMCre+ mice also displayed SLE-like clinical manifestations, including alopecia, lymphadenopathy, splenomegaly, proteinuria, significant increases in anti-dsDNA antibodies, IFN-α, IL-6, and decreased complement C3 levels, indicating a close association between decreased neutrophil GPX4 protein expression and SLE pathogenesis. This evidence concerns the gene C3 and Splenomegaly.