For example, pathogenic Yersinia that cause diseases ranging from plague to gastroenteritis, use a sophisticated bacterial type 3 secretion system to inject YopJ, a bacterial acetyltransferase into mammalian cells to inhibit the central signalling kinase (TGF-beta-activated kinase 1) TAK1 and dismantle downstream NF-κB and MAPKs activation [6]. Here, MAP3K7 is linked to plague.