To explore whether HNF4A-liver-TEs is essential for KDM1A-mediated inhibition of HNF4A expression, we overexpressed KDM1A in HCC cells depleted of HNF4A-liver-TEs, which resulted in the loss of the ability of KDM1A to suppress HNF4A expression (Fig. 3f). The gene discussed is KDM1A; the disease is hepatocellular carcinoma.