RNA-seq analysis of ECs isolated from manifest aneurysms of the ascending arch of the AngII ApoE−/− mice vs ECs from the same segment of sham animals confirmed upregulation of DEGs related to the categories of ECM organization, TGFbeta signaling, angiogenesis and cytokine activity as well as acute inflammation (Fig. 6M). The gene discussed is APOE; the disease is aneurysm.