APOE and aneurysm: The gene expression pattern we found in ECs from aneurysms of the AngII ApoE−/− model fits very well to reported pathophysiological mechanisms of aneurysm formation that have been identified in whole aortic tissues of aneurysms: We detected changes of ECM-related genes such as collagens [118], metalloproteinases and proteoglycans/glycoproteins [119] and a dysregulation of lysyloxidase (LOX) expression [120].