NPPB and Stroke: Patients who experienced stroke were similar to the remainder except for lower LVEF by 11% (P = 0.041) at baseline (Table 1) In the former group higher creatinine by 13% (P = 0.013), NT-proBNP by 265% (P < 0.001), and vWF by 18% (P = 0.01) were noticed.