In summary, based on previous studies by our group, in this study, Lathyrol inhibited the expression of invasive proteins and the incidence of EMT in RCC xenografts through the inhibition of the expression of AR and SPHK-2, key proteins in RCC xenografts, thus significantly inhibiting the invasion and EMT ability of RCC xenografts in mice; notably, Lathyrol had a small effect on the body weight of the mice. This evidence concerns the gene SPHK2 and renal cell carcinoma.