The activation of the PI3K/Akt signalingcascade, mediated by an array of enzymes, enhances cellular glucoseuptake and diminishes extracellular glucose concentrations, therebyeffectively mitigating hyperglycemia.17 Here, in the perigonadal adipose tissue, a marked diminution wasobserved in the relative protein levels of pPI3K/PI3K, pAkt/Akt, andGLUT4 by 62.3, 78.1, and 85.7%, respectively, in the HFD group comparedto the ND group (p < 0.05). This evidence concerns the gene AKT1 and Hyperglycemia.