TNF and obesity due to melanocortin 4 receptor deficiency: FT significantly enhanced insulinsignaling, as evidenced by theupregulation of PI3K/Akt pathway proteins in adipose and liver tissues,crucial for reducing insulin resistance (Figures 4A–E and 5A,B).Additionally, FT reduced pro-inflammatory cytokines such as IL-6,MCP-1, TNF-α, and IL-1β, which are implicated in obesity-relatedlow-grade inflammation (Figure 6).