ADORA2A and Alzheimer disease: Considering the prime role of A2AR in synaptic fine-tuning,5,11 the aberrant plasticity changes associated with its neuronal dysregulation in aged and AD conditions21 as well as the beneficial impact of its pharmacological or genetic blockade against memory and hippocampal plasticity impairments in models of amyloidogenesis or amyloid toxicity,5,13-15,17-21 we hypothesized that pathological neuronal upregulation of A2AR might favour AD lesion development and synaptic alterations promoted by amyloid pathology.