When we compared gene expression from modules M4 (Supplementary Fig. 10A) to our previous results obtained in our tauopathy mouse model, Thy-Tau22 mice (RNA-seq data from Carvalho et al. 27), we observed the same effect as in APP/PS1 mice, i.e. no effect of the presence of A2AR but synergy with the presence of either APP/PS1 or Tau22 genotypes on synaptic pathways27 (Figs 5B and 7, proteomic data). This evidence concerns the gene APP and tauopathy.