MAPT and Alzheimer disease type 1: Considering the pathophysiological link between amyloid and tau in AD1 and our recent demonstration that neuronal A2AR upregulation impacts tau phosphorylation in a mouse model of tauopathy,27 we also evaluated the levels of murine phospshorylated tau (p-tau) and total tau in the hippocampal parenchyma of APP/PS1 and APP/PS1 A2A mice and found no significant differences (P > 0.05, Student’s t-test; Fig. 3G).