Aberrant levels of ceramide have been shown to be toxic to retinal ganglion cells (Fan et al., 2021), photoreceptor (German et al., 2006; Chen et al., 2013), and RPE cells (Levitsky et al., 2020), providing a likely explanation for the retinal toxicity associated with CORD21 retinal dystrophy. Here, DRAM2 is linked to inherited retinal dystrophy.