The predominant cone phenotype preceding the loss of rods in Cln10−/−mice (Bassal et al., 2021) is consistent with the classical presentation of CORD21 macular dystrophy (El-Asrag et al., 2015; Sergouniotis et al., 2015; Abad-Morales et al., 2019; Bassal et al., 2021); however, the CORD21-ROs did not reveal changes in the expression of mature cone and rod markers in agreement with the adult onset of CORD21 clinical phenotype (Krašovec et al., 2022). Here, CTSD is linked to Macular dystrophy.