DRAM2 and Macular dystrophy: The predominant cone phenotype preceding the loss of rods in Cln10−/−mice (Bassal et al., 2021) is consistent with the classical presentation of CORD21 macular dystrophy (El-Asrag et al., 2015; Sergouniotis et al., 2015; Abad-Morales et al., 2019; Bassal et al., 2021); however, the CORD21-ROs did not reveal changes in the expression of mature cone and rod markers in agreement with the adult onset of CORD21 clinical phenotype (Krašovec et al., 2022).