DRAM2 and autosomal recessive cone rod dystrophy: CORD21 autosomal recessive cone-rod dystrophy is associated with biallelic mutations in DRAM2. We report that CORD21 patient-derived ROs and RPE cells demonstrate aberrant autophagy, a significant depletion of lysosomal enzymes, and lysosomal contents accumulation, which may underlie CORD21 disease.