Recent studies comparing lung adenocarcinoma development in the KrasG12D/+;p53fl/fl GEMM with either Keap1R554Q or Nrf2D29H expressed under the control of the endogenous Nrf2 promoter found that the levels of Nrf2 pathway activity are important for tumor initiation, progression and histological grade [23]. This evidence concerns the gene NFE2L2 and neoplasm.