INS and obesity due to melanocortin 4 receptor deficiency: Adipose tissue (AT) is home of an abundance of immune cells, which increase during obesity developing an immunological setting perturbing the insulin signaling.3 Time-resolved single-cell characterization of AT revealed that a subtype of WAT-resident macrophages called lipid-associated macrophages (LAMs) controls cell heterogeneity in the adipose niche in obesity.4–6