ALDH1A3 and melanoma: Indeed, in our two independent melanoma cell lines (control vs. ALDH1A3 KO), we detected higher levels of 13C2-labeled acetylated histone H3 proteins in cells with high ALDH1A3 activity, with the incorporation at H3K14ac and H3K23ac especially responsive to ALDH1A3 levels (Figure 4B, left panel).