Given these data, we re-analyzed single-cell RNA-seq (scRNA-seq) data from 15 patient melanoma samples47 and found that ALDH1A3 and TFAP2B are co-expressed in a distinct cell cluster present in five out of 15 samples of varied mutation subtypes, indicating that there are enough cells in this state to form a cluster and that this cluster does not simply come from a single patient or genotype (Figures 1G and S1M). The gene discussed is TFAP2B; the disease is melanoma.