In this retrospective cohort study on patients with S. saccharolyticus detection, we found that patients with a likely infection had more often pathogen detection in blood culture(s), a longer length of hospital stay, a higher maximal body temperature during the hospital stay, higher CRP levels, were more likely to be treated with antibiotics, were more likely to be treated at an ICU, and had a longer stay at an ICU. The gene discussed is CRP; the disease is infection.