PLOD1 and coronary artery disorder: Also, as emerged from the Women’s Ischemia Syndrome Evaluation, in a study of coronary angiography in women with coronary risk factors, estrogen deficiency was associated with low levels of LH and FSH correlating with the presence of coronary artery disease, and the diagnosis of hypoestrogenemia of hypothalamic origin was found to be an independent risk for coronary heart disease.