Of the surveillance-detected malignant lesions, most (68%) were invasive; of these, the median size was 15mm (IQR 7–20mm), 37% were Grade 3, 19% were node-positive, and ER/PR + HER2- cancers were the most common (56%) followed by TNBC/’ER-low positive’ (26%) (Table 4). Here, ESR1 is linked to cancer.