Furthermore, systemic overexpression of ADAM17 induced macrophage infiltration and subsequent fibrosis in adipose tissue under a high-fat diet regimen, increased TNF-α serum levels, general inflammation, and macrophage-related cytokines (INF-y, IL-1b, MCP-1) [77], demonstrating the sufficient actions of this protease in the development of T2DM. Here, TNF is linked to type 2 diabetes mellitus.