The primary clinically used anti-diabetes drugs are sulfonylureas, biguanides, α-glucosidase inhibitors (AGIs), thiazolidinediones (TZDs), sodium-glucose cotransporter type 2 inhibitors (SGLT2i), dipeptidyl peptidase-4 inhibitors (DPP-4Is), glucagon-like peptide-1 receptor agonists (GLP-1RAs), and insulin analogs [146]. This evidence concerns the gene INS and diabetes mellitus.