Although the detailed mechanisms underlying the discrepancy in the efficacy of CB1/TRPV1 ligands between the anxiety‐ and working memory impairment‐related behaviours remain elusive, the differences in the relevant brain regions,112, 113, 114, 115 along with polymodal regulation of synaptic plasticity involved in the two neurotransmitter systems,116, 117 seemed to contribute, and this may be controlled subtly at the epigenetic level. Here, CNR1 is linked to Anxiety.