We have previously shown exogenous ADAMTS13 did not significantly change plasma levels of VWF antigen but increased levels of cleaved VWF, reduced the adhesive activity of VWF measured by the collagen‐binding assay, reduced platelet activation measured by CD62p expression and improved outcomes of mice with traumatic brain injury38 and endotoxemia.39 This evidence concerns the gene SELP and serum lipopolysaccharide activity.