To further determine the protective role of Snord3a deficiency in AKI progression, we established an IRI‐induced AKI model in Snord3afl/fl‐GGT1Cre mice and Snord3afl/fl mice (Figure S4A, Supporting Information), noting significant Snord3a knockdown efficiency through FISH staining and RT‐PCR analysis (Figure S3D, Supporting Information). The gene discussed is SNORD3A; the disease is acute kidney injury.