GPX4 and acute kidney injury: Conrad et al. also elucidated the essential role of the GSH/GPX4 axis in preventing lipid‐oxidation‐induced acute renal failure and ferroptotic cell death using inducible GPX4(‐/‐) mice.[25] Our research suggests that Snord3a inhibits the normal biology of GPX4 and ACSL4 in lipid metabolism, leading to lipid peroxides accumulation and GSH depletion.