MLKL is among the most significantly upregulated genes in various models of AKI, and RIPK3 and MLKL deficient mice have shown protection from the IRI model.[27] Recently, studies have shown that GSDMD plays a protective role in renal tubules by preventing necroptosis‐mediated damage during the AKI process. The gene discussed is MLKL; the disease is acute kidney injury.