Studies have reported high expression of Snord3a in breast cancer, osteosarcoma, and hepatocellular carcinoma, where it serves as a diagnostic molecular marker.[21] Liu et al. observed that Snord3a enhanced cell proliferation and reprogrammed energy metabolism in glioblastoma.[22] Moreover, Tim et al. indicated that impaired expression of Snord3a in osteoarthritis affected chondrocyte phenotype and inflammation by regulating translation capacity.[23] Despite these findings, the biological role and molecular functions of Snord3a in kidney diseases have remained elusive. Here, SNORD3A is linked to osteoarthritis.