Mechanistically, the role of DUSP1 in PCa progression and its impact on patient outcomes have been widely reported by negatively regulating p38 MAPK signaling pathway.[21, 39, 40] The bone metastasis model of PCa showed that knockdown of PROPER expression or elevation of DUSP1 expression significantly inhibited tumor cell‐induced bone erosion of proximal tibiae compared to the control group (Figure 7H; Figure S9F, Supporting Information). The gene discussed is DUSP1; the disease is neoplasm.