Cancer cells can fuse with neighboring cells (mesenchymal stromal cells – MSCs, fibroblasts, immune cells or other cancer cells) giving rise to tumor hybrid cells (THC) which exhibit high aggressiveness, drug resistance and ability to dodge immunity.[176] Montalban‐Hernandez and colleagues obtained CD45+CD14+EpCAM+ THCs from fusion between CRC stem cells and human monocytes after 5 days of co‐culture, displaying enhanced metastatic abilities. Here, EPCAM is linked to neoplasm.