In this system, ECM density and laminin were both proven as critical factors regulating cancer cell invasion and vascular network formation.[190] Interestingly, a number of recent studies based on microfluidic approaches attempted to reproduce the complex 3D TME through the control of fluid volumes, cell compartmentalization, paracrine signals and microvasculature, mimicking different features of TME such as cells‐crosstalk, angiogenesis, molecular gradients, microbiome or drug response. The gene discussed is LAMB2; the disease is cancer.