The adhesion of tumor spheroids to colon epithelium and myofibroblast monolayers modulated the proinflammatory cytokines IL‐1 beta, IL‐6, TNF‐alpha and radicals (ROS and NO) levels in a tumor grade‐dependent manner, with a significant increase of IL‐6 production in advanced CRC. The gene discussed is IL6; the disease is neoplasm.