Furthermore, heightened expression of FUN14 Domain Containing 2 (FUNDC2) promotes mitochondrial transport of phosphatidylinositol-3,4,5-trisphosphate (PIP3), which modulates neuronal AkT/Foxo3a signaling in a model of cerebral ischemia/reperfusion, consequently increasing the expression of bim (Shi et al., 2021). The gene discussed is FOXO3; the disease is brain ischemia.