ELP1 and neoplasm: A familial history of MB was found in only 1 of these 11 families: as depicted in the pedigree in Figure 4A, 1 second-cousin (ELP1-Fr6) of the proband (ELP1-Fr5) was a carrier of the familial PV and also affected by an MB, but many asymptomatic carriers were identified in the family, including a majority of adults beyond the upper age of tumor-onset observed in our series.