This has been largely discussed for patients baring TP53, PTCH1 or SUFU constitutional PV.9,11 Here we show that: (i) ELP1 PV predispose to SHH-MB of any risk group, (ii) the prognosis of ELP1-associated MBs is similar to those of sporadic cases with the same risk factors, and (iii) finally, no short-term unexpected or remarkable toxicity was retrospectively recorded using classical treatments. This evidence concerns the gene ELP1 and Mobius syndrome.