CHI3L1 has been identified as a pro-fibrotic factor; it is overexpressed in aging livers and in patients with hepatic cirrhosis, thus given its key role in the development of hepatic fibrosis through direct action on HSCs and promotion of susceptibility to fibrosis in aging livers (34), CHI3L1 serves as a biomarker of hepatic fibrosis. The gene discussed is CHI3L1; the disease is Cirrhosis.