In the sarcopenia dataset, BTG2 (AUC = 0.867), CDKN1A (AUC = 0.892), CEBPB (AUC = 0.942), DDIT4 (AUC = 0.792), FOXO3 (AUC = 0.900), NFKBIA (AUC = 0.892), ZBTB16 (AUC = 0.808) and ZFP36 (AUC = 0.775) demonstrated better diagnostic efficacy in distinguishing sarcopenia patients from healthy controls. Here, ZBTB16 is linked to sarcopenia.