A previous study demonstrated that Runt-related transcription factor-1 (Runx1), renowned for its roles in hemopoiesis and leukaemia, possesses the ability to regulate crucial genes such as collagen type II (Col2a1) and X (Col10a1), SRY-box transcription factor 9 (Sox9), aggrecan (Acan), and matrix metalloproteinase 13 (MMP-13). This evidence concerns the gene ACAN and leukemia.