MCM4 and osteosarcoma: Genes within these families have all been found to be mutated/dysregulated on osteosarcomas, with TP53, MUC4, MUC6, MUC17, TDG, MCM4, PER3, CDC27, and CCNE1 mutation/dysregulation having specifically been previously identified in osteosarcomas [15, 19–26].