RB1 and osteosarcoma: Kovac et al. [15] analyzed 123 osteosarcomas and identified 14 gene mutations as the main drivers in 87% of osteosarcoma cases, including TP53, RB1, BRCA2, BAP1, RET, MUTYH, ATM, PTEN, WRN, RECQL4, ATRX, FANCA, NUMA1, and MDC1.