One mechanism, by which the tumor cells escape the host’s immune response is the hijacking of immune-checkpoints, like programmed cell death ligand 1 (PD-L1), CD80, CD86 and their respective receptors, programmed death receptor 1 (PD-1) and cytotoxic T-cells associated protein 4 (CTLA-4). The gene discussed is CD86; the disease is neoplasm.