AIF1 and neoplasm: Iba-1 positive cells in tumor ROI showed a significant decline between groups from 3288.8 cells per mm2 (85.26%) to 2523.3 per mm2 (53.22%), while CD3 positive cells showed an increase from 1039.9 per mm2 (11.3%) to 3225.4 per mm2 (53.5%) in group 1 and 4, respectively (p < 0.05; Figure 1).