We found that the abundant transcripts and proteins of IFN-α, IFN-β, IFN-γ, and IFN-λ1 were detected in PRRSV-infected PAMs in early infection, and weak inhibition of IFN-α, IFN-β, IFN-γ, and IFN-λ1 was observed in PRRSV-infected PAMs in late infection, consistent with previous studies (31, 45–47). This evidence concerns the gene IFNB1 and infection.