As shown in Figures 4, 5, the mRNAs of IFN-α, IFN-β, IFN-γ, IFN-λ1, and TNF-α in PRRSV-infected cells pretreated with NICs, and their proteins in cell supernatants were significantly decreased at 12–72 h post-infection, whereas the mRNAs of IL-10 and TGF-β1 in PRRSV-infected cells pretreated with NICs and their proteins in cell supernatants were significantly increased at 12–72 h post-infection compared with PRRSV-infected cells pretreated with PNI + RNI. This evidence concerns the gene IFNL1 and infection.