Other than that, it was revealed that the G domain of laminin-α2 is crucial; thus, when aberrant, it results in MDC1A in up to 41% of patients, with no implication in cases of LGMD-like phenotype. Lastly, the observation that the same genotype with the same level of laminin-α2 expression can lead to different phenotypes underscores the potential influence of other genetic or epigenetic factors on the final phenotype and disease prognosis in patients. The gene discussed is LAMA2; the disease is limb-girdle muscular dystrophy.