The second phase, spanning 2017 to 2020, explores keywords such as ‘amyloid precursor protein, HD, neurofibrillary tangles, antioxidant, peroxidation, inactivation, cell death mechanisms, metabolism, toxicity, heme oxygenase 1, Friedreich’s ataxia,’ emphasizing the impact of ferroptosis on ND. Here, APP is linked to Friedreich ataxia.