CYP2D6 and colon adenocarcinoma: Pharmacokinetic properties include absorption (human intestinal absorption (HIA) and human colon adenocarcinoma cells (Caco-2)), distribution (plasma protein binding (PPB) and blood-brain barrier (BBB)), metabolism (CYP2D6 and CYP3A4 as substrate and inhibition), and toxicity test (mutagenic and carcinogenic) were predicted in compounds of papaya leaves before further stages (clinical trials).