Pharmacokinetic properties include absorption (human intestinal absorption (HIA) and human colon adenocarcinoma cells (Caco-2)), distribution (plasma protein binding (PPB) and blood-brain barrier (BBB)), metabolism (CYP2D6 and CYP3A4 as substrate and inhibition), and toxicity test (mutagenic and carcinogenic) were predicted in compounds of papaya leaves before further stages (clinical trials). This evidence concerns the gene CYP3A4 and colon adenocarcinoma.