In pancreatic cancer, the prognosis of patients with high expression of ECM enzymes‐cleaved collagens I was worse than patients with high expression of intact collagens I.32Our study suggested that the ECM was in a state of lysis in oral carcinogenesis, and Fib_S100a4 might be responsible for the remodeling of ECM; however, the specific roles and mechanisms of Fib_S100a4 in oral carcinogenesis should be future studied. This evidence concerns the gene S100A4 and familial pancreatic carcinoma.