In the setting of stress-promoted carcinogenesis, the Y box binding protein-1 (YB-1) was previously reported to link adrenergic signaling to β-catenin mediated chemoresistance in hepatocellular carcinoma (Liu et al., 2020) and pancreatic cancer (Shan et al., 2013). The gene discussed is YBX1; the disease is familial pancreatic carcinoma.