GPT and Sepsis: In a mouse model of sepsis with acute liver injury induced by LPS, the new HG derivative 14 (Figure 1), with a pyrazine ring bonded to ring A, suppressed the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), attenuated the inflammatory response, and protected against liver injury.