BECN1 and breast carcinoma: In a breast cancer-bearing mouse model, Shang et al. discovered that HG activated autophagy by facilitating the generation of autophagosomes, increasing the expression of Beclin-1, and encouraging the transformation of LC3-I to LC3-II, concurrently promoting mitochondria-mediated apoptosis, to exert its anti-breast cancer effect (Shang et al., 2019).