EGFR and non-small cell lung carcinoma: Moreover, this derivative strongly inhibited the activity of mutant EGFR-L858R/T790M/C797S kinase and the proliferation of previous generations of EGFR tyrosine kinase inhibitor-resistant H1975 and H1975-LTC NSCLC cell lines, as well as generating the most nitrite via the synergistic effect of HG and NO donors (Chen et al., 2019).