Tumor growth inhibition mediated by HG was related to the induction of apoptosis through the mitochondrial pathway, as exemplified by disrupting MMP, inducing the generation of ROS, elevating the activation of caspase-9 and caspase-3, upregulating Bax, and downregulating Bcl-2, Bcl-xL, and Survivin. This evidence concerns the gene CASP9 and neoplasm.