This complex of nanoparticles selectively accumulates in tumor sites, triggering ferroptosis by inducing ROS production and regulating the expression of KEAP1, NRF2, and HMOX1, which in turn elevates the labile iron pool in 4T1 tumor-bearing BALB/c model mice (Zhao et al., 2023b). This evidence concerns the gene KEAP1 and neoplasm.