The clustering pattern of HBx 3’ end generates a truncated X protein (Ct-HBx) (62) that promotes HCC progression by mediating glucose metabolism reprogramming, increasing matrix metalloproteinase 10 (MMP10) transcription (62, 63), and enhancing Wnt/β-Catenin signaling (64). Here, MMP10 is linked to hepatocellular carcinoma.