The p38 and PI3K/AKT pathways mediate the PRL-3-induced TGF-β1 by activating FAK and developing another positive feedback loop (144).Thus, TGF-β interacts with multiple carcinogenic pathways in tumors, and blocking TGF-β activation could serve as a vital approach in the treatment of liver cancer. Here, TGFB1 is linked to liver cancer.