The development of n-GH, which is considered an acute exacerbation of IgAN via the activation of mucosal immunity, likely involves increased production of galactose-deficient-IgA1 (Gd-IgA1) and activation of the complementary system, both of which are reported to be stimulated by the COVID-19 mRNA vaccine [3, 4]. This evidence concerns the gene IGHA1 and COVID-19.