FHL2 and cardiac arrhythmia: He was heterozygous for a synonymous SNP in CACNA1C (p.G1738G;c.5358C>T, f = 1.21E-5), and for non-synonymous missense variants of uncertain significance in genes associated with cardiomyopathy and arrhythmia, including a variant in ANK2 (p.R2416G;c.7246C>G, unreported), a variant in FHL2 (p.V187M;c.559G>A, f = 6.78E-5), and two variants in TTN (p.A31503T;c94507G>A, f = 5.04E-5 and p.F14410C;c.43229T>G, unreported) (Table 1).