PTPN2 and colitis: Based on the results that expression of TCPTP in macrophages was confirmed higher in the Pichia/IL-35-treated group than that of the untreated group in vitro and in vivo experiments, we speculated that Pichia/IL-35 mediated the attenuation of DSS-induced colitis in mice at least partly regulates macrophage through the upregulation of TCPTP.