CD4 and colitis: Wirtz et al. [63] revealed that the mucosa in EBI3-deficient mice with spontaneous or T-cell transfer-induced colitis infiltrated large amounts of activated CD4+ T cells producing Th1 and Th17 cytokines, and recombinant IL-35 treatment significantly ameliorated the colitis and decreased proportions of Th1 and Th17 cells.