While the exact role of IFITM3 and the other IFITM family members in tumorigenesis remains the focus of intensive investigation, these findings suggest that CRC progression is not simply related to the intensity of ISG induction, but rather the precise composition of the ISG program, the influence of other regulatory pathways, and ultimately, the net effects of many positive and negative determinants of tumor growth. Here, IFITM3 is linked to neoplasm.