The striking findings of the present study were as follows: (1) the value of NLR and MLR were significantly higher in STEMI patients who underwent PPCI with HTB; (2) more participants in the HTB group had a TIMI blood flow of 3 immediately after PPCI compared to those in the LTB group; (3) the level of CRP, baseline troponin I, and baseline BNP were higher in the high NLR group than in the low NLR group in STEMI patients with HTB; and (4) an elevated NLR was associated with MACEs and heart failure in STEMI patients who underwent PPCI with HTB. Here, CRP is linked to heart failure.