Logic AND-gating circumvent on-target-off-tumor toxicity but in consequence lead to a sensitivity decrease of the CAR T cells since the CAR requires two independent signals for efficient CAR activation, e.g., the AND-gating of a dual-CAR construct [CEA-CD3ζ & MSLN-4-1BB] in which the CEA-CAR provides the CD3ζ signaling and the MSLN-CAR provides the 4-1BB costimulatory signaling (176). This evidence concerns the gene CEACAM5 and neoplasm.