Our research highlights the nuanced roles of SLC7A11 and POU4F1 in COAD, where SLC7A11 overexpression may inhibit metastasis, in contrast with the ability of POU4F1 to facilitate tumor growth and migration, suggesting that gene functions vary significantly across cancers due to unique genetic and epigenetic landscapes (29). The gene discussed is POU4F1; the disease is neoplasm.