Utilizing the IVW method and various sensitivity analyses, we identified strong associations between specific immune signatures such as CD25 on IgD- CD24- cells, CD27 on IgD+ CD24+ cells, CCR2 on monocyte cells, and CD123 on both CD62L+ and plasmacytoid dendritic cells with the development of lung cancer. The gene discussed is CD27; the disease is lung carcinoma.