Matrix metalloproteinase 1 (MMP-1), N-cadherin, E-cadherin, Epcam, CDK 6, RHOU, INSM 1, and RASSF10 were found to be increased in serum exosomes in invasive NFPA patients compared with non-invasive NFPA patients. This evidence concerns the gene MMP1 and non-functioning pituitary adenoma.