Duthika and colleagues performed a proteomic analysis of glioma-derived exosomes and found that five genes [Annexin A1 (ANXA 1), Actin-Associated Protein 3 (ACTR 3), Integrin- β 1 (ITGB 1), Insulin-like Growth Factor 2 Receptor (IGF2R), and Programmed Cell Death 6 Interacting Protein (PDCD6IP)] were highly expressed in GBM tumors than normal brain tissue-derived exosomes. This evidence concerns the gene IGF2R and glioma.