Through, transcriptomic and proteomic analysis of variants of noninvasive and invasive pituitary adenomas and other forms of pituitary adenomas, Ren et al. demonstrated that the expression of matrix metalloproteinase-1 (MMP-1) was upregulated and its formation in exosomes was associated with the aggressiveness of nfpa, that is, MMP1 mRNA and protein were specifically localized to exoinfpa, and the MMP 1 activity was transferred to other tumor cells and vascular endothelial cells [57]. This evidence concerns the gene MMP1 and pituitary gland adenoma.