MSP–RON cascade can regulate neuroinflammation process by exerting neuroprotective effect in multiple sclerosis and experimental autoimmune encephalomyelitis.35 MSP-deficient animals with experimental autoimmune encephalomyelitis induction showed an earlier onset of neurological dysfunctions such as exacerbated demyelination, axonal injury and neuroinflammation.35 Another study revealed that MSP is over-expressed and activated in malignant gliomas, which can stimulate glioma proliferation, migration, invasion and vascularization in vivo. This evidence concerns the gene MST1 and malignant glioma.