IL6R and rectum adenocarcinoma: We found that in most common malignancy, RA pathogenic genes are negatively correlated with them (Figure 5A), including colon adenocarcinoma (COAD), renal chromophobe (KICH), lung squamous cell carcinoma (LUSC) and rectal adenocarcinoma (READ), etc. IL6R has the highest correlation with COAD and READ, and may be a key gene in reducing the risk of colorectal cancer in RA patients.